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rna interference and micro rna –oriented therapy in cancer: rationales, promises, and challenges

The discovery that rna interference (rnai) and its functional derivatives, small interfering rnas (sirnas) and micro-rnas (mirnas) could mediate potent and specific gene silencing has raised high hopes for cancer therapeutics. The prevalence of these small (18–25 nucleotide) non-coding rnas in human...

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Detalles Bibliográficos
Autores principales: Duchaine, T.F., Slack, F.J.
Formato: Texto
Lenguaje:English
Publicado: Multimed Inc. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722055/
https://www.ncbi.nlm.nih.gov/pubmed/19672426
Descripción
Sumario:The discovery that rna interference (rnai) and its functional derivatives, small interfering rnas (sirnas) and micro-rnas (mirnas) could mediate potent and specific gene silencing has raised high hopes for cancer therapeutics. The prevalence of these small (18–25 nucleotide) non-coding rnas in human gene networks, coupled with their unique specificity, has paved the way for the development of new and promising therapeutic strategies in re-directing or inhibiting small rna phenomena. Three strategies are currently being developed: De novo rnai programming using synthetic sirnas to target the expression of genes. Strengthening or recapitulation of the physiologic targeting of messenger rnas by specific mirnas. Sequence-specific inhibition of mi rna functions by nucleic acid analogs. Each strategy, currently being developed both in academia and in industry, holds promise in cancer therapeutics.