Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy

In synucleinopathies, including Parkinson's disease, partially ubiquitylated α-synuclein species phosphorylated on serine 129 (P(S129)-α-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal recessive parkinsonism, protects against α-synuclein-...

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Detalles Bibliográficos
Autores principales: Fournier, Margot, Vitte, Jérémie, Garrigue, Jérôme, Langui, Dominique, Dullin, Jean-Philippe, Saurini, Françoise, Hanoun, Naïma, Perez-Diaz, Fernando, Cornilleau, Fabien, Joubert, Chantal, Ardila-Osorio, Héctor, Traver, Sabine, Duchateau, René, Goujet-Zalc, Cécile, Paleologou, Katerina, Lashuel, Hilal A., Haass, Christian, Duyckaerts, Charles, Cohen-Salmon, Charles, Kahle, Philipp J., Hamon, Michel, Brice, Alexis, Corti, Olga
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722082/
https://www.ncbi.nlm.nih.gov/pubmed/19680561
http://dx.doi.org/10.1371/journal.pone.0006629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722082/
https://www.ncbi.nlm.nih.gov/pubmed/19680561
http://dx.doi.org/10.1371/journal.pone.0006629

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