Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is a critical negative regulator of immune responses. Uniquely among known inhibitory receptors, its genetic ablation results in a fulminating and fatal lymphoproliferative disorder. This central regulatory role led to the development of antibodie...

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Detalles Bibliográficos
Autores principales: Peggs, Karl S., Quezada, Sergio A., Chambers, Cynthia A., Korman, Alan J., Allison, James P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722174/
https://www.ncbi.nlm.nih.gov/pubmed/19581407
http://dx.doi.org/10.1084/jem.20082492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722174/
https://www.ncbi.nlm.nih.gov/pubmed/19581407
http://dx.doi.org/10.1084/jem.20082492

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