Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide

We herein report a faster and less cumbersome synthesis of the biologically attractive, α-galactosyl ceramide (α-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular glycosylation reaction gave easy access to the diglycosyl ceramide Gal(α1→2)Ga...

Descripción completa

Detalles Bibliográficos
Autores principales: Veerapen, Natacha, Brigl, Manfred, Garg, Salil, Cerundolo, Vincenzo, Cox, Liam R., Brenner, Michael B., Besra, Gurdyal S.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722241/
https://www.ncbi.nlm.nih.gov/pubmed/19502056
http://dx.doi.org/10.1016/j.bmcl.2009.05.095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722241/
https://www.ncbi.nlm.nih.gov/pubmed/19502056
http://dx.doi.org/10.1016/j.bmcl.2009.05.095

Ejemplares similares