Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

The intraerythrocytic parasite Plasmodium—the causative agent of malaria—produces an inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is released into the circulation during erythrocyte lysis. Hz is rapidly ingested by phagocytes and induces the production of seve...

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Detalles Bibliográficos
Autores principales: Tiemi Shio, Marina, Eisenbarth, Stephanie C., Savaria, Myriam, Vinet, Adrien F., Bellemare, Marie-Josée, Harder, Kenneth W., Sutterwala, Fayyaz S., Bohle, D. Scott, Descoteaux, Albert, Flavell, Richard A., Olivier, Martin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722371/
https://www.ncbi.nlm.nih.gov/pubmed/19696895
http://dx.doi.org/10.1371/journal.ppat.1000559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722371/
https://www.ncbi.nlm.nih.gov/pubmed/19696895
http://dx.doi.org/10.1371/journal.ppat.1000559

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