Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens

Indoleamine 2,3-dioxygenase (IDO) is the first enzyme in the kynurenine pathway. The kynurenines formed in this pathway chemically modify proteins and cause apoptosis in cells. Evidence suggests that kynurenines and their protein modifications are involved in cataract formation, but this has yet to...

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Detalles Bibliográficos
Autores principales: Mailankot, Maneesh, Staniszewska, Magdalena, Butler, Heather, Caprara, Moonkyung, Howell, Scott, Wang, Benlian, Doller, Catherine, Reneker, Lixing, Nagaraj, Ram H
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722445/
https://www.ncbi.nlm.nih.gov/pubmed/19308046
http://dx.doi.org/10.1038/labinvest.2009.22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722445/
https://www.ncbi.nlm.nih.gov/pubmed/19308046
http://dx.doi.org/10.1038/labinvest.2009.22

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