Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes

BACKGROUND: In von Hippel-Lindau (VHL) disease, germline mutations in the VHL tumor suppressor gene cause clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product is part of an ubiquitin E3 ligase complex and hypoxia-inducible factor alpha (HIF-α) is a key substrat...

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Detalles Bibliográficos
Autores principales: Bangiyeva, Valentina, Rosenbloom, Ava, Alexander, Ashlynn E, Isanova, Bella, Popko, Timothy, Schoenfeld, Alan R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722669/
https://www.ncbi.nlm.nih.gov/pubmed/19602254
http://dx.doi.org/10.1186/1471-2407-9-229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722669/
https://www.ncbi.nlm.nih.gov/pubmed/19602254
http://dx.doi.org/10.1186/1471-2407-9-229

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