RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway

BACKGROUND: Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are overexpressed in melanoma and may contribute to melanoma's striking resistance to apoptosis. ABT-737, a small-molecule inhi...

Descripción completa

Detalles Bibliográficos
Autores principales: Keuling, Angela M., Felton, Kathleen E. A., Parker, Arabesque A. M., Akbari, Majid, Andrew, Susan E., Tron, Victor A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722728/
https://www.ncbi.nlm.nih.gov/pubmed/19684859
http://dx.doi.org/10.1371/journal.pone.0006651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722728/
https://www.ncbi.nlm.nih.gov/pubmed/19684859
http://dx.doi.org/10.1371/journal.pone.0006651

Ejemplares similares