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RNA Silencing of Mcl-1 Enhances ABT-737-Mediated Apoptosis in Melanoma: Role for a Caspase-8-Dependent Pathway

BACKGROUND: Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are overexpressed in melanoma and may contribute to melanoma's striking resistance to apoptosis. ABT-737, a small-molecule inhi...

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Detalles Bibliográficos
Autores principales:	Keuling, Angela M., Felton, Kathleen E. A., Parker, Arabesque A. M., Akbari, Majid, Andrew, Susan E., Tron, Victor A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722728/ https://www.ncbi.nlm.nih.gov/pubmed/19684859 http://dx.doi.org/10.1371/journal.pone.0006651

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