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Competition between Intramolecular and Intermolecular Interactions in an Amyloid-Forming Protein

Despite much progress in understanding the folding and the aggregation processes of proteins, the rules defining their interplay have yet to be fully defined. This problem is of particular importance since many diseases are initiated by protein unfolding and hence the propensity to aggregate compete...

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Detalles Bibliográficos
Autores principales: Routledge, Katy E., Tartaglia, Gian Gaetano, Platt, Geoffrey W., Vendruscolo, Michele, Radford, Sheena E.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722902/
https://www.ncbi.nlm.nih.gov/pubmed/19393661
http://dx.doi.org/10.1016/j.jmb.2009.04.042