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Rare codon content affects the solubility of recombinant proteins in a codon bias-adjusted Escherichia coli strain
BACKGROUND: The expression of heterologous proteins in Escherichia coli is strongly affected by codon bias. This phenomenon occurs when the codon usage of the mRNA coding for the foreign protein differs from that of the bacterium. The ribosome pauses upon encountering a rare codon and may detach fro...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723077/ https://www.ncbi.nlm.nih.gov/pubmed/19630980 http://dx.doi.org/10.1186/1475-2859-8-41 |