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Rare codon content affects the solubility of recombinant proteins in a codon bias-adjusted Escherichia coli strain

BACKGROUND: The expression of heterologous proteins in Escherichia coli is strongly affected by codon bias. This phenomenon occurs when the codon usage of the mRNA coding for the foreign protein differs from that of the bacterium. The ribosome pauses upon encountering a rare codon and may detach fro...

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Detalles Bibliográficos
Autores principales:	Rosano, Germán L, Ceccarelli, Eduardo A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723077/ https://www.ncbi.nlm.nih.gov/pubmed/19630980 http://dx.doi.org/10.1186/1475-2859-8-41

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