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The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

BACKGROUND: Brain tissue from patients with Alzheimer's disease has shown an increase of phosphorylation of Tyr-682, located on the conserved Y682ENPTY motif, and Thr-668 residues, both in the intracellular domain (AID) of amyloid β precursor protein (APP), although the role of these two residu...

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Detalles Bibliográficos
Autores principales: Tamayev, Robert, Zhou, Dawang, D'Adamio, Luciano
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723102/
https://www.ncbi.nlm.nih.gov/pubmed/19602287
http://dx.doi.org/10.1186/1750-1326-4-28