Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing

A single tumor may contain cells with different somatic mutations. By characterizing this genetic heterogeneity within tumors, advances have been made in the prognosis, treatment and understanding of tumorigenesis. In contrast, the extent of epigenetic intra-tumor heterogeneity and how it influences...

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Detalles Bibliográficos
Autores principales: Varley, Katherine E., Mutch, David G., Edmonston, Tina B., Goodfellow, Paul J., Mitra, Robi D.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724279/
https://www.ncbi.nlm.nih.gov/pubmed/19494183
http://dx.doi.org/10.1093/nar/gkp457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724279/
https://www.ncbi.nlm.nih.gov/pubmed/19494183
http://dx.doi.org/10.1093/nar/gkp457

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