Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

BACKGROUND: Glucocorticoid function is dependent on efficient translocation of the glucocorticoid receptor (GR) from the cytoplasm to the nucleus of cells. Importin-13 (IPO13) is a nuclear transport receptor that mediates nuclear entry of GR. In airway epithelial cells, inhibition of IPO13 expressio...

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Detalles Bibliográficos
Autores principales: Raby, Benjamin A, Van Steen, Kristel, Lasky-Su, Jessica, Tantisira, Kelan, Kaplan, Feige, Weiss, Scott T
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724419/
https://www.ncbi.nlm.nih.gov/pubmed/19619331
http://dx.doi.org/10.1186/1465-9921-10-67

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724419/
https://www.ncbi.nlm.nih.gov/pubmed/19619331
http://dx.doi.org/10.1186/1465-9921-10-67

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