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Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria
30 years before the discovery of the pfcrt gene, altered cellular drug accumulation in drug-resistant malarial parasites had been well documented. Heme released from catabolized hemoglobin was thought to be a key target for quinoline drugs, and additional modifications to quinoline drug structure in...
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| Formato: | Texto |
| Lenguaje: | English |
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Future Medicine Ltd
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724744/ https://www.ncbi.nlm.nih.gov/pubmed/19416013 http://dx.doi.org/10.2217/fmb.09.15 |