Resistant mutants of Mycobacterium tuberculosis selected in vitro do not reflect the in vivo mechanism of isoniazid resistance

OBJECTIVES: The high prevalence of isoniazid-resistant Mycobacterium tuberculosis is often explained by a high mutation rate for this trait, although detailed information to support this theory is absent. We studied the development of isoniazid resistance in vitro, making use of a laboratory strain...

Descripción completa

Detalles Bibliográficos
Autores principales: Bergval, Indra L., Schuitema, Anja R. J., Klatser, Paul R., Anthony, Richard M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724981/
https://www.ncbi.nlm.nih.gov/pubmed/19578178
http://dx.doi.org/10.1093/jac/dkp237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724981/
https://www.ncbi.nlm.nih.gov/pubmed/19578178
http://dx.doi.org/10.1093/jac/dkp237

Ejemplares similares