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Apoptosis of t(14;18)-positive lymphoma cells by a Bcl-2 interacting small molecule
Overexpression of Bcl-2 protein occurs via both t(14;18)-dependent and independent mechanisms and contributes to the survival and chemoresistance of non-Hodgkin lymphomas. HA14–1 is a nonpeptidic organic small molecule, which has been shown to inhibit the interaction of Bcl-2 with Bax, thereby inter...
Autores principales: | Abbott, David R., Abbott, Robert T., Jenson, Stephen D., Fillmore, G. Chris, Elenitoba-Johnson, Kojo S. J., Lim, Megan S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725288/ https://www.ncbi.nlm.nih.gov/pubmed/19669197 http://dx.doi.org/10.1007/s12308-009-0028-x |
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