Interrogating and Predicting Tolerated Sequence Diversity in Protein Folds: Application to E. elaterium Trypsin Inhibitor-II Cystine-Knot Miniprotein

Cystine-knot miniproteins (knottins) are promising molecular scaffolds for protein engineering applications. Members of the knottin family have multiple loops capable of displaying conformationally constrained polypeptides for molecular recognition. While previous studies have illustrated the potent...

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Detalles Bibliográficos
Autores principales: Lahti, Jennifer L., Silverman, Adam P., Cochran, Jennifer R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725296/
https://www.ncbi.nlm.nih.gov/pubmed/19730675
http://dx.doi.org/10.1371/journal.pcbi.1000499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725296/
https://www.ncbi.nlm.nih.gov/pubmed/19730675
http://dx.doi.org/10.1371/journal.pcbi.1000499

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