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OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background
BACKGROUND: Leber's hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA) are the most frequent forms of hereditary optic neuropathies. LHON is associated with mitochondrial DNA (mtDNA) mutations whereas ADOA is mainly due to mutations in the OPA1 gene that encodes a mi...
Autores principales: | Pierron, Denis, Ferré, Marc, Rocher, Christophe, Chevrollier, Arnaud, Murail, Pascal, Thoraval, Didier, Amati-Bonneau, Patrizia, Reynier, Pascal, Letellier, Thierry |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726129/ https://www.ncbi.nlm.nih.gov/pubmed/19619285 http://dx.doi.org/10.1186/1471-2350-10-70 |
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