AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC

The innate immune system senses nucleic acids via germ-line encoded pattern recognition receptors. RNA is sensed via Toll-like receptor (TLR)−3, −7 and −8 or by the RNA helicases RIG-I and MDA-51. Little is known about sensors for cytoplasmic DNA which trigger antiviral and/or inflammatory responses...

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Detalles Bibliográficos
Autores principales: Hornung, Veit, Ablasser, Andrea, Charrel-Dennis, Marie, Bauernfeind, Franz, Horvath, Gabor, Caffrey, Daniel R., Latz, Eicke, Fitzgerald, Katherine A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726264/
https://www.ncbi.nlm.nih.gov/pubmed/19158675
http://dx.doi.org/10.1038/nature07725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726264/
https://www.ncbi.nlm.nih.gov/pubmed/19158675
http://dx.doi.org/10.1038/nature07725

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