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AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
The innate immune system senses nucleic acids via germ-line encoded pattern recognition receptors. RNA is sensed via Toll-like receptor (TLR)−3, −7 and −8 or by the RNA helicases RIG-I and MDA-51. Little is known about sensors for cytoplasmic DNA which trigger antiviral and/or inflammatory responses...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726264/ https://www.ncbi.nlm.nih.gov/pubmed/19158675 http://dx.doi.org/10.1038/nature07725 |