Structural Impact of the E113Q Counterion Mutation on the Activation and Deactivation Pathways of the G Protein-coupled Receptor Rhodopsin

Disruption of an interhelical salt bridge between the retinal protonated Schiff base linked to H7 and Glu113 on H3 is one of the decisive steps during activation of rhodopsin. Using previously established stabilization strategies, we engineered a stabilized E113Q counterion mutant that converted rho...

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Detalles Bibliográficos
Autores principales: Standfuss, Jörg, Zaitseva, Ekaterina, Mahalingam, Mohana, Vogel, Reiner
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726285/
https://www.ncbi.nlm.nih.gov/pubmed/18511075
http://dx.doi.org/10.1016/j.jmb.2008.04.055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726285/
https://www.ncbi.nlm.nih.gov/pubmed/18511075
http://dx.doi.org/10.1016/j.jmb.2008.04.055

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