A muscle-targeting peptide displayed on AAV2 improves muscle tropism upon systemic delivery

Adeno-associated virus (AAV) has become a leading gene transfer vector for striated muscles. However, the AAV vectors also exhibit broad tropisms after systemic delivery. In an attempt to improve muscle tropism, we inserted a 7-amino-acid (ASSLNIA) muscle-targeting peptide (MTP) in the capsids of AA...

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Detalles Bibliográficos
Autores principales: Yu, Chi-Yi, Yuan, Zhenhua, Cao, Zhongren, Wang, Bing, Qiao, Chunping, Li, Juan, Xiao, Xiao
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726895/
https://www.ncbi.nlm.nih.gov/pubmed/19474807
http://dx.doi.org/10.1038/gt.2009.59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726895/
https://www.ncbi.nlm.nih.gov/pubmed/19474807
http://dx.doi.org/10.1038/gt.2009.59

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