Impact of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of ondansetron and dexamethasone

INTRODUCTION: Pharmacokinetic interactions between casopitant (a substrate and weak to moderate inhibitor of CYP3A), dexamethasone (a substrate and weak inducer of CYP3A), and ondansetron (a mixed CYP substrate) were evaluated in a two-part, three-period, single-sequence study in two groups of healt...

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Detalles Bibliográficos
Autores principales: Johnson, Brendan, Adams, Laurel, Lu, Emily, Zhang, Ke, Lebowitz, Peter, Lates, Christian, Blum, Robert
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726912/
https://www.ncbi.nlm.nih.gov/pubmed/19205755
http://dx.doi.org/10.1007/s00520-008-0571-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726912/
https://www.ncbi.nlm.nih.gov/pubmed/19205755
http://dx.doi.org/10.1007/s00520-008-0571-5

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