Selection on cis-Regulatory Variation at B4galnt2 and Its Influence on von Willebrand Factor in House Mice

The RIIIS/J inbred mouse strain is a model for type 1 von Willebrand disease (VWD), a common human bleeding disorder. Low von Willebrand factor (VWF) levels in RIIIS/J are due to a regulatory mutation, Mvwf1, which directs a tissue-specific switch in expression of a glycosyltransferase, B4GALNT2, fr...

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Detalles Bibliográficos
Autores principales: Johnsen, Jill M., Teschke, Meike, Pavlidis, Pavlos, McGee, Beth M., Tautz, Diethard, Ginsburg, David, Baines, John F.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727395/
https://www.ncbi.nlm.nih.gov/pubmed/19088380
http://dx.doi.org/10.1093/molbev/msn284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727395/
https://www.ncbi.nlm.nih.gov/pubmed/19088380
http://dx.doi.org/10.1093/molbev/msn284

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