A Mapping of Drug Space from the Viewpoint of Small Molecule Metabolism

Small molecule drugs target many core metabolic enzymes in humans and pathogens, often mimicking endogenous ligands. The effects may be therapeutic or toxic, but are frequently unexpected. A large-scale mapping of the intersection between drugs and metabolism is needed to better guide drug discovery...

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Detalles Bibliográficos
Autores principales: Adams, James Corey, Keiser, Michael J., Basuino, Li, Chambers, Henry F., Lee, Deok-Sun, Wiest, Olaf G., Babbitt, Patricia C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727484/
https://www.ncbi.nlm.nih.gov/pubmed/19701464
http://dx.doi.org/10.1371/journal.pcbi.1000474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727484/
https://www.ncbi.nlm.nih.gov/pubmed/19701464
http://dx.doi.org/10.1371/journal.pcbi.1000474

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