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A Mapping of Drug Space from the Viewpoint of Small Molecule Metabolism
Small molecule drugs target many core metabolic enzymes in humans and pathogens, often mimicking endogenous ligands. The effects may be therapeutic or toxic, but are frequently unexpected. A large-scale mapping of the intersection between drugs and metabolism is needed to better guide drug discovery...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727484/ https://www.ncbi.nlm.nih.gov/pubmed/19701464 http://dx.doi.org/10.1371/journal.pcbi.1000474 |