Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo

OBJECTIVE: Intravenous adenosine induces temporary bradycardia. This is due to the activation of extracellular adenosine receptors (ARs). While adenosine can signal through any of four ARs (A1AR, A2AAR, A2BAR, A3AR), previous ex vivo studies implicated the A1AR in the heart-rate slowing effects. Her...

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Detalles Bibliográficos
Autores principales: Koeppen, Michael, Eckle, Tobias, Eltzschig, Holger K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727950/
https://www.ncbi.nlm.nih.gov/pubmed/19707555
http://dx.doi.org/10.1371/journal.pone.0006784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727950/
https://www.ncbi.nlm.nih.gov/pubmed/19707555
http://dx.doi.org/10.1371/journal.pone.0006784

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