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Ribosomal Synthesis of N-Methyl Peptides

[Image: see text] N-Methyl amino acids (N-Me AAs) are a common component of nonribosomal peptides (NRPs), a class of natural products from which many clinically important therapeutics are obtained. N-Me AAs confer peptides with increased conformational rigidity, membrane permeability, and protease r...

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Detalles Bibliográficos
Autores principales: Subtelny, Alexander O., Hartman, Matthew C. T., Szostak, Jack W.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728122/
https://www.ncbi.nlm.nih.gov/pubmed/18402453
http://dx.doi.org/10.1021/ja710016v