Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents

PURPOSE: Breast cancer treatment often employs DNA double-strand breaks (DSBs), such as that induced by irradiation or anticancer agents. Ubiquitination is required at the site of DNA damage and plays a crucial role in the DSB repair pathway. We investigated the effect of proteasome inhibitors on th...

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Detalles Bibliográficos
Autores principales: Takeshita, Takashi, Wu, Wenwen, Koike, Ayaka, Fukuda, Mamoru, Ohta, Tomohiko
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728221/
https://www.ncbi.nlm.nih.gov/pubmed/19274461
http://dx.doi.org/10.1007/s00280-009-0961-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728221/
https://www.ncbi.nlm.nih.gov/pubmed/19274461
http://dx.doi.org/10.1007/s00280-009-0961-5

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