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Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents

PURPOSE: Breast cancer treatment often employs DNA double-strand breaks (DSBs), such as that induced by irradiation or anticancer agents. Ubiquitination is required at the site of DNA damage and plays a crucial role in the DSB repair pathway. We investigated the effect of proteasome inhibitors on th...

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Detalles Bibliográficos
Autores principales:	Takeshita, Takashi, Wu, Wenwen, Koike, Ayaka, Fukuda, Mamoru, Ohta, Tomohiko
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728221/ https://www.ncbi.nlm.nih.gov/pubmed/19274461 http://dx.doi.org/10.1007/s00280-009-0961-5

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