Rapid Selection of Cyclic Peptides that Reduce α-Synuclein Toxicity in Yeast and Animal Models

Phage display has demonstrated the utility of cyclic peptides as general protein ligands, but cannot access proteins inside eukaryotic cells. Expanding a novel chemical genetics tool, we describe the first expressed library of head-to-tail cyclic peptides in yeast (Saccharomyces cerevisiae). We appl...

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Detalles Bibliográficos
Autores principales: Kritzer, Joshua A., Hamamichi, Shusei, McCaffery, J. Michael, Santagata, Sandro, Naumann, Todd A., Caldwell, Kim A., Caldwell, Guy A., Lindquist, Susan
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729362/
https://www.ncbi.nlm.nih.gov/pubmed/19597508
http://dx.doi.org/10.1038/nchembio.193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729362/
https://www.ncbi.nlm.nih.gov/pubmed/19597508
http://dx.doi.org/10.1038/nchembio.193

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