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Rapid Selection of Cyclic Peptides that Reduce α-Synuclein Toxicity in Yeast and Animal Models
Phage display has demonstrated the utility of cyclic peptides as general protein ligands, but cannot access proteins inside eukaryotic cells. Expanding a novel chemical genetics tool, we describe the first expressed library of head-to-tail cyclic peptides in yeast (Saccharomyces cerevisiae). We appl...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729362/ https://www.ncbi.nlm.nih.gov/pubmed/19597508 http://dx.doi.org/10.1038/nchembio.193 |