Targeting Hypoxia in Cancer Cells by Restoring Homeodomain Interacting Protein-Kinase 2 and p53 Activity and Suppressing HIF-1α

BACKGROUND: The tumor suppressor homeodomain-interacting protein kinase-2 (HIPK2) by phosphorylating serine 46 (Ser46) is a crucial regulator of p53 apoptotic function. HIPK2 is also a transcriptional co-repressor of hypoxia-inducible factor-1α (HIF-1α) restraining tumor angiogenesis and chemoresist...

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Detalles Bibliográficos
Autores principales: Nardinocchi, Lavinia, Puca, Rosa, Sacchi, Ada, Rechavi, Gideon, Givol, David, D'Orazi, Gabriella
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729407/
https://www.ncbi.nlm.nih.gov/pubmed/19714248
http://dx.doi.org/10.1371/journal.pone.0006819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729407/
https://www.ncbi.nlm.nih.gov/pubmed/19714248
http://dx.doi.org/10.1371/journal.pone.0006819

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