Foxp3 instability leads to the generation of pathogenic memory T cells in vivo

Regulatory T (T(reg)) cells play a central role in maintaining immune homeostasis. However, little is known about the stability of T(reg) cells in vivo. In this study, we demonstrate that a significant percentage of cells exhibited transient or unstable Foxp3 expression. These exFoxp3(+) T cells exp...

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Detalles Bibliográficos
Autores principales: Zhou, Xuyu, Bailey-Bucktrout, Samantha, Jeker, Lukas T., Penaranda, Cristina, Martínez-Llordella, Marc, Ashby, Meredith, Nakayama, Maki, Rosenthal, Wendy, Bluestone, Jeffrey A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729804/
https://www.ncbi.nlm.nih.gov/pubmed/19633673
http://dx.doi.org/10.1038/ni.1774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729804/
https://www.ncbi.nlm.nih.gov/pubmed/19633673
http://dx.doi.org/10.1038/ni.1774

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