Eradication of Chronic Myeloid Leukemia Stem Cells: A Novel Mathematical Model Predicts No Therapeutic Benefit of Adding G-CSF to Imatinib

Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy. Bone marrow studies have shown that this residual disease resides within the stem cell com...

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Detalles Bibliográficos
Autores principales: Foo, Jasmine, Drummond, Mark W., Clarkson, Bayard, Holyoake, Tessa, Michor, Franziska
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730033/
https://www.ncbi.nlm.nih.gov/pubmed/19749982
http://dx.doi.org/10.1371/journal.pcbi.1000503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730033/
https://www.ncbi.nlm.nih.gov/pubmed/19749982
http://dx.doi.org/10.1371/journal.pcbi.1000503

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