Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation

Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process. In order to try to model neuronal dysfunction associated with mitochondr...

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Detalles Bibliográficos
Autores principales: Kirby, D. M. , Rennie, K. J. , Smulders‐Srinivasan, T. K. , Acin‐Perez, R. , Whittington, M. , Enriquez, J.‐A. , Trevelyan, A. J. , Turnbull, D. M. , Lightowlers, R. N. 
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730481/
https://www.ncbi.nlm.nih.gov/pubmed/19552636
http://dx.doi.org/10.1111/j.1365-2184.2009.00612.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730481/
https://www.ncbi.nlm.nih.gov/pubmed/19552636
http://dx.doi.org/10.1111/j.1365-2184.2009.00612.x

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