A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection

We report a follicular lymphoma (FL) case presenting the coexistence of two tumor cell subpopulations in lymph node (LN) and bone marrow (BM), which exhibited an inverse pattern of immunoglobulin light (IgL) chain gene rearrangement and expression: Igκ−λ+ in LN and Igκ+λ− in BM. These tumor clones s...

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Detalles Bibliográficos
Autores principales: Nakamura, Yuichi, Sato, Yasutaka, Yoshida, Katsuhiko, Kakegawa, Emi, Ito, Yoshihiro, Seyama, Atsushi, Kayano, Hidekazu, Bessho, Masami
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730550/
https://www.ncbi.nlm.nih.gov/pubmed/19220419
http://dx.doi.org/10.1111/j.1600-0609.2009.01233.x
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author Nakamura, Yuichi
Sato, Yasutaka
Yoshida, Katsuhiko
Kakegawa, Emi
Ito, Yoshihiro
Seyama, Atsushi
Kayano, Hidekazu
Bessho, Masami
author_facet Nakamura, Yuichi
Sato, Yasutaka
Yoshida, Katsuhiko
Kakegawa, Emi
Ito, Yoshihiro
Seyama, Atsushi
Kayano, Hidekazu
Bessho, Masami
author_sort Nakamura, Yuichi
collection PubMed
description We report a follicular lymphoma (FL) case presenting the coexistence of two tumor cell subpopulations in lymph node (LN) and bone marrow (BM), which exhibited an inverse pattern of immunoglobulin light (IgL) chain gene rearrangement and expression: Igκ−λ+ in LN and Igκ+λ− in BM. These tumor clones shared an identical BCL2-IgH recombination, accompanying t(14;18)(q32;q21) translocation, and an identical variable, diversity and joining segments joining with clone-specific VH somatic hypermutations on the untranslocated IgH allele. Our study provides further evidence that FL clones, originating from common progenitor cells, can be developed independently at different sites and with different IgL expression after immune selection.
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spelling pubmed-27305502009-08-27 A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection Nakamura, Yuichi Sato, Yasutaka Yoshida, Katsuhiko Kakegawa, Emi Ito, Yoshihiro Seyama, Atsushi Kayano, Hidekazu Bessho, Masami Eur J Haematol Case Report We report a follicular lymphoma (FL) case presenting the coexistence of two tumor cell subpopulations in lymph node (LN) and bone marrow (BM), which exhibited an inverse pattern of immunoglobulin light (IgL) chain gene rearrangement and expression: Igκ−λ+ in LN and Igκ+λ− in BM. These tumor clones shared an identical BCL2-IgH recombination, accompanying t(14;18)(q32;q21) translocation, and an identical variable, diversity and joining segments joining with clone-specific VH somatic hypermutations on the untranslocated IgH allele. Our study provides further evidence that FL clones, originating from common progenitor cells, can be developed independently at different sites and with different IgL expression after immune selection. Blackwell Publishing Ltd 2009-05 /pmc/articles/PMC2730550/ /pubmed/19220419 http://dx.doi.org/10.1111/j.1600-0609.2009.01233.x Text en © 2009 John Wiley & Sons A/S http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Case Report
Nakamura, Yuichi
Sato, Yasutaka
Yoshida, Katsuhiko
Kakegawa, Emi
Ito, Yoshihiro
Seyama, Atsushi
Kayano, Hidekazu
Bessho, Masami
A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
title A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
title_full A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
title_fullStr A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
title_full_unstemmed A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
title_short A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
title_sort molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730550/
https://www.ncbi.nlm.nih.gov/pubmed/19220419
http://dx.doi.org/10.1111/j.1600-0609.2009.01233.x
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