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Investigation and prediction of the severity of p53 mutants using parameters from structural calculations
A method has been developed to predict the effects of mutations in the p53 cancer suppressor gene. The new method uses novel parameters combined with previously established parameters. The most important parameter is the stability measure of the mutated structure calculated using molecular modelling...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730554/ https://www.ncbi.nlm.nih.gov/pubmed/19558493 http://dx.doi.org/10.1111/j.1742-4658.2009.07124.x |