Heterozygous Mutation of Drosophila Opa1 Causes the Development of Multiple Organ Abnormalities in an Age-Dependent and Organ-Specific Manner

Optic Atrophy 1 (OPA1) is a ubiquitously expressed dynamin-like GTPase in the inner mitochondrial membrane. It plays important roles in mitochondrial fusion, apoptosis, reactive oxygen species (ROS) and ATP production. Mutations of OPA1 result in autosomal dominant optic atrophy (DOA). The molecular...

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Detalles Bibliográficos
Autores principales: Shahrestani, Parvin, Leung, Hung-Tat, Le, Phung Khanh, Pak, William L., Tse, Stephanie, Ocorr, Karen, Huang, Taosheng
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730818/
https://www.ncbi.nlm.nih.gov/pubmed/19718456
http://dx.doi.org/10.1371/journal.pone.0006867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730818/
https://www.ncbi.nlm.nih.gov/pubmed/19718456
http://dx.doi.org/10.1371/journal.pone.0006867

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