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The CREB Coactivator CRTC2 Links Hepatic ER Stress and Fasting Gluconeogenesis
In fasted mammals, circulating pancreatic glucagon stimulates hepatic gluconeogenesis in part through the CREB Regulated Transcription Coactivator 2 (CRTC2; also referred to as TORC2) 1,2. Hepatic glucose production is elevated in obesity, reflecting chronic increases in endoplasmic reticulum (ER) s...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730924/ https://www.ncbi.nlm.nih.gov/pubmed/19543265 http://dx.doi.org/10.1038/nature08111 |