Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands

BACKGROUND: Targeting of protein antigens to dendritic cells (DC) via the DEC205 receptor enhances presentation of antigen-derived peptides on MHC-I and MHC-II molecules and, in the presence of costimulatory signals, antigen-specific immune responses. The immunogenicity and efficacy of DNA vaccinati...

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Detalles Bibliográficos
Autores principales: Grossmann, Claudius, Tenbusch, Matthias, Nchinda, Godwin, Temchura, Vladimir, Nabi, Ghulam, Stone, Geoffrey W, Kornbluth, Richard S, Überla, Klaus
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731061/
https://www.ncbi.nlm.nih.gov/pubmed/19650904
http://dx.doi.org/10.1186/1471-2172-10-43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731061/
https://www.ncbi.nlm.nih.gov/pubmed/19650904
http://dx.doi.org/10.1186/1471-2172-10-43

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