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Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands

BACKGROUND: Targeting of protein antigens to dendritic cells (DC) via the DEC205 receptor enhances presentation of antigen-derived peptides on MHC-I and MHC-II molecules and, in the presence of costimulatory signals, antigen-specific immune responses. The immunogenicity and efficacy of DNA vaccinati...

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Detalles Bibliográficos
Autores principales:	Grossmann, Claudius, Tenbusch, Matthias, Nchinda, Godwin, Temchura, Vladimir, Nabi, Ghulam, Stone, Geoffrey W, Kornbluth, Richard S, Überla, Klaus
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731061/ https://www.ncbi.nlm.nih.gov/pubmed/19650904 http://dx.doi.org/10.1186/1471-2172-10-43

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