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An in silico study of the molecular basis of B-RAF activation and conformational stability
BACKGROUND: B-RAF kinase plays an important role both in tumour induction and maintenance in several cancers and it is an attractive new drug target. However, the structural basis of the B-RAF activation is still not well understood. RESULTS: In this study we suggest a novel molecular basis of B-RAF...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731097/ https://www.ncbi.nlm.nih.gov/pubmed/19624854 http://dx.doi.org/10.1186/1472-6807-9-47 |