Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic β-Cells

OBJECTIVE: Prolonged exposure of pancreatic β-cells to simultaneously elevated levels of fatty acids and glucose (glucolipotoxicity) impairs insulin gene transcription. However, the intracellular signaling pathways mediating these effects are mostly unknown. This study aimed to ascertain the role of...

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Detalles Bibliográficos
Autores principales: Fontés, Ghislaine, Semache, Meriem, Hagman, Derek K., Tremblay, Caroline, Shah, Ramila, Rhodes, Christopher J., Rutter, Jared, Poitout, Vincent
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731539/
https://www.ncbi.nlm.nih.gov/pubmed/19502418
http://dx.doi.org/10.2337/db08-0579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731539/
https://www.ncbi.nlm.nih.gov/pubmed/19502418
http://dx.doi.org/10.2337/db08-0579

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