Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy

BACKGROUND: In affected sibling pair linkage analysis, the presence of linkage disequilibrium (LD) has been shown to lead to overestimation of the number of alleles shared identity-by-descent (IBD) among sibling pairs when parents are ungenotyped. This inflation results in spurious evidence for link...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Kelly, Dupuis, Josée
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731784/
https://www.ncbi.nlm.nih.gov/pubmed/19664279
http://dx.doi.org/10.1186/1471-2156-10-44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731784/
https://www.ncbi.nlm.nih.gov/pubmed/19664279
http://dx.doi.org/10.1186/1471-2156-10-44

Ejemplares similares