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Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy
BACKGROUND: In affected sibling pair linkage analysis, the presence of linkage disequilibrium (LD) has been shown to lead to overestimation of the number of alleles shared identity-by-descent (IBD) among sibling pairs when parents are ungenotyped. This inflation results in spurious evidence for link...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731784/ https://www.ncbi.nlm.nih.gov/pubmed/19664279 http://dx.doi.org/10.1186/1471-2156-10-44 |