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Using reads to annotate the genome: influence of length, background distribution, and sequence errors on prediction capacity

Ultra high-throughput sequencing is used to analyse the transcriptome or interactome at unprecedented depth on a genome-wide scale. These techniques yield short sequence reads that are then mapped on a genome sequence to predict putatively transcribed or protein-interacting regions. We argue that fa...

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Detalles Bibliográficos
Autores principales: Philippe, Nicolas, Boureux, Anthony, Bréhélin, Laurent, Tarhio, Jorma, Commes, Thérèse, Rivals, Éric
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731892/
https://www.ncbi.nlm.nih.gov/pubmed/19531739
http://dx.doi.org/10.1093/nar/gkp492