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Senescence delay and repression of p16(INK4a) by Lsh via recruitment of histone deacetylases in human diploid fibroblasts
Lymphoid specific helicase (Lsh) belongs to the family of SNF2/helicases. Disruption of Lsh leads to developmental growth retardation and premature aging in mice. However, the specific effect of Lsh on human cellular senescence remains unknown. Herein, we report that Lsh overexpression delays cell s...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731912/ https://www.ncbi.nlm.nih.gov/pubmed/19561196 http://dx.doi.org/10.1093/nar/gkp533 |